top of page



Avila-Zozaya M., Rodríguez-Hernández B., Monterrubio-Ledezma F., Cisneros B., Boucard A.A. (2022) Thwarting of Lphn3 Functions in Cell Motility and Signaling by Cancer-Related GAIN Domain Somatic Mutations. Cells 11(12):1913. doi: 10.3390/cells11121913.

Boucard, A.A. (2022) Self-activated adhesion receptor proteins visualized. Nature 604 (7907): 628-630.  doi: 10.1038/d41586-022-00972-0.

Moreno-Salinas A.L., Holleran B.J., Ojeda-Muñiz E.Y., Correoso-Braña K.G., Ribalta-Mena S., Ovando-Zambrano J.C., Leduc R., Boucard A.A. (2022) Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility. Mol Psychiatry 27(5):2425-2438. doi: 10.1038/s41380-022-01537-3.


Antony A. Boucard (2020) Ancestry‐Tracking of Stress Response GPCR Clades: A Conceptual Path to Treating Depression. BioEssays e2000170. doi: 10.1002/bies.202000170. PMID : 32734610.

David A. Lovejoy, Antony A. Boucard and Richard P. Tucker (2020) Editorial: Origins of Human Neuropathology: The Significance of Teneurin-Latrophilin Interaction. Frontiers in Neuroscience vol 14 (501), 1-3.


Cruz-Ortega, J.S., Boucard, A.A. (2019) Actin Cytoskeleton Remodeling Defines a Distinct Cellular Function for Adhesion G Protein-Coupled Receptors ADGRL/Latrophilins 1, 2 and 3. Biol. Open 8 (4) pii: bio039826. doi: 10.1242/bio.039826.


Moreno-Salinas, A.L., Avila-Zozaya, M., Ugalde-Silva, P., Hernández-Guzmán D.A., Missirlis, F., Boucard, A.A. (2019) Latrophilins: A Neuro-centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily. Frontiers in Neuroscience 13: 700. doi: 10.3389/fnins.2019.00700. eCollection 2019.


Ovando-Zambrano, J.-C., Arias-Montaño, J.-A., Boucard, A.A. (2019) Alternative Splicing Event Modifying ADGRL/Latrophilin-1 Cytoplasmic Tail Promotes Both Opposing and Dual cAMP Signaling Pathways. Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.14198.


Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. (2019) The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.14094.




Meza-Aguilar, D.G. & Boucard, A.A. (2014) Latrophilins Updated. Biomol Concepts 5 (6): 457-478.


Tsetsenis T, Boucard A.A., Araç D, Brunger AT, Südhof TC. (2014) Direct Visualization of Trans-Synaptic Neurexin-Neuroligin Interactions during Synapse Formation. J Neurosci. 34(45): 15083-15096.


Boucard, A.A., Maxeiner, S., Sudhof, T.C. Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins: Regulation By Alternative Splicing. J. Biol. Chem. 289(1): 387-402.




Boucard, A.A., Ko, J., Sudhof, T.C. High-Affinity Neurexin Binding to the Cell-Adhesion G-protein Coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex. J. Biol. Chem. 287(12): 9399-9413.


Arac, D., Boucard A.A., Bolliger, M.F., Nguyen, J., Soltis, M., Sudhof T.C., Brunger, A.T. A Novel Evolutionarily Conserved Domain of Cell-Adhesion GPCRs Mediates Autoproteolysis. EMBO J. 31(6): 1364-1378.




Robbins E.M., Krupp A.J., Perez de Arce K., Ghosh A.K., Fogel A.I., Boucard A., Südhof T.C., Stein V., Biederer T. SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68(5): 894-906.




Ko J., Zhang C., Arac D., Boucard A.A., Brunger A.T., Südhof T.C. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28(20): 3244-3255.


Zhang C., Milunsky J.M., Newton S., Ko J., Zhao G., Maher T.A., Tager-Flusberg H., Bolliger M.F., Carter A.S., Boucard A.A., Powell C.M., Südhof T.C. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci. 29(35): 10843-10854.




Proulx C.D., Holleran B.J., Boucard A.A., Escher E., Guillemette G., Leduc R. Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor. Mol Pharmacol. 74(3): 552-561.


Bolliger M.F., Pei J., Maxeiner S., Boucard A.A., Grishin N.V., Südhof T.C. Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A. 105(17): 6421-6426.




Araç D., Boucard, A.A., Strop, P., Sudhof, T.C. & Brunger, A.T. Structures of Neuroligin-1, and the Neuroligin-1/β-Neurexin-1 complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56(6): 992-1003.



Comoletti, D., Flynn, R. E., Boucard, A.A., Demeler, B., Shirf, V., Shi, J., Jennings, L.L., Newlin, H.R., Sudhof, T.C. & Taylor, P. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45(42): 12816-12827.




Boucard A.A., Chubykin, A. A., Comoletti, D., Taylor, P. & Sudhof T.C. A Splice-code for trans-synaptic cell adhesion mediated by binding of Neuroligin 1 to a- and b-Neurexins. Neuron 48 (2): 229-236.




Martin, S.S., Boucard, A.A., Clément, M., Escher, E., Leduc, R. & Guillemette G. Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine-scanning mutagenesis. J. Biol. Chem. 279 (49): 51415-51423.




Boucard, A.A., Roy, M., Beaulieu, M.E., Lavigne, P., Escher, E., Guillemette, G. & Leduc, R. Constitutive activation of the Angiotensin II type-1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket. J. Biol. Chem. 278 (38) : 36628-36636.


Boucard, A.A., Sauvé, S., Guillemette, G., Escher, E. & Leduc, R. Photolabelling the rat urotensinII/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain. Biochem. J. 370 (Pt. 3): 829-838.




Rihakova, L., Deraet, M., Auger-Messier, M., Pérodin, J., Boucard, A.A., Guillemette, G., Leduc, R., Lavigne, P. & Escher, E. Methionine proximity assay, a novel method for exploring peptide-ligand interaction. J. Recept. Signal Transduct. Res. 22 (1-4): 297-313.


Pérodin, J., Deraet, M, .Auger-Messier, M., Boucard, A.A., Rihakova, L., Beaulieu, M.E., Lavigne, P., Parent, J.L., Guillemette, G., Leduc, R. & Escher, E. Residues 293 and 294 are ligand contact points for the human angiotensin type 1 receptor. Biochemistry 41(48): 14348-14356.


Deraet, M., Rhihakova, L., Boucard, A.A., Sauvé, S., Mathieu, A.P., Guillemette,G., Leduc, R., Lavigne, P. & Escher, E. Angiotensin II bound to both receptors AT1 and AT2, parallel to the transmembrane domains and in an extended form. Can J Physiol Pharmacol. 80(5): 418-425.




Pérodin, J, Boucard, A.A., Leduc, R., Escher, E. & Guillemette, G. Assays for radiolabel-photoaffinity labeling of Angiotensin receptors. Methods Mol. Med. 51: 297-303.




Boucard A.A., Wilkes, B.C., Laporte, S.A., Escher, E., Guillemette, G. & Leduc, R. Photolabeling identifies position 172 of the human AT1 receptor as a ligand contact point: receptor-bound angiotensin II adopts an extended structure. Biochemistry 39(32): 9662-9670.




Laporte, S.A., Boucard, A.A., Servant, G., Guillemette, G., Leduc, R. & Guillemette, G. Determination of peptide contact points in the human angiotensin II type I receptor (AT1) with photosensitive analogs of angiotensin II. Mol Endocrinol. 13(4): 578-586.



.Book Chapters


Pérodin, J, Boucard, A.A., Leduc, R., Escher, E. & Guillemette, G. (2000). Assays for radiolabel-photoaffinity labeling of angiotensin receptors. Methods in Molecular Medecine vol. 51: Angiotensin Protocols, editors D.H. Wang, Humana Press Inc., Totowa, NJ.


Powell,C.M., Boucard, A. A. (2010) Neurexins and neuroligins: synaptic bridges implicated in autism. The Neurochemical Basis of Autism: From molecules to minicolumns, editors Gene J. Blatt, Springer, New York.


Powell,C.M., Boucard, A.A. (2012) Neuroligins and Neurexins: Bridging the synaptic cleft in Autism. The Autisms: Molecules to Model Systems, editors Powell C.M. & Monteggia L.M., Oxford University Press, New York.


bottom of page