.Publications

.2019

Cruz-Ortega, J.S., Boucard, A.A. (2019) Actin Cytoskeleton Remodeling Defines a Distinct Cellular Function for Adhesion G Protein-Coupled Receptors ADGRL/Latrophilins 1, 2 and 3. Biol. Open 8 (4) pii: bio039826. doi: 10.1242/bio.039826.

 

Moreno-Salinas, A.L., Avila-Zozaya, M., Ugalde-Silva, P., Hernández-Guzmán D.A., Missirlis, F., Boucard, A.A. (2019) Latrophilins: A Neuro-centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily. Frontiers in Neuroscience 13: 700. doi: 10.3389/fnins.2019.00700. eCollection 2019.

 

Ovando-Zambrano, J.-C., Arias-Montaño, J.-A., Boucard, A.A. (2019) Alternative Splicing Event Modifying ADGRL/Latrophilin-1 Cytoplasmic Tail Promotes Both Opposing and Dual cAMP Signaling Pathways. Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.14198.

 

Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S, Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. (2019) The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Ann. N. Y. Acad. Sci. doi: 10.1111/nyas.14094.

 

.2014

 

Meza-Aguilar, D.G. & Boucard, A.A. (2014) Latrophilins Updated. Biomol Concepts 5 (6): 457-478.

 

Tsetsenis T, Boucard A.A., Araç D, Brunger AT, Südhof TC. (2014) Direct Visualization of Trans-Synaptic Neurexin-Neuroligin Interactions during Synapse Formation. J Neurosci. 34(45): 15083-15096.

 

Boucard, A.A., Maxeiner, S., Sudhof, T.C. Latrophilins Function as Heterophilic Cell-adhesion Molecules by Binding to Teneurins: Regulation By Alternative Splicing. J. Biol. Chem. 289(1): 387-402.

 

.2012

 

Boucard, A.A., Ko, J., Sudhof, T.C. High-Affinity Neurexin Binding to the Cell-Adhesion G-protein Coupled Receptor CIRL1/Latrophilin-1 Produces an Intercellular Adhesion Complex. J. Biol. Chem. 287(12): 9399-9413.

 

Arac, D., Boucard A.A., Bolliger, M.F., Nguyen, J., Soltis, M., Sudhof T.C., Brunger, A.T. A Novel Evolutionarily Conserved Domain of Cell-Adhesion GPCRs Mediates Autoproteolysis. EMBO J. 31(6): 1364-1378.

 

.2010

 

Robbins E.M., Krupp A.J., Perez de Arce K., Ghosh A.K., Fogel A.I., Boucard A., Südhof T.C., Stein V., Biederer T. SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68(5): 894-906.

 

.2009

 

Ko J., Zhang C., Arac D., Boucard A.A., Brunger A.T., Südhof T.C. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J. 28(20): 3244-3255.

 

Zhang C., Milunsky J.M., Newton S., Ko J., Zhao G., Maher T.A., Tager-Flusberg H., Bolliger M.F., Carter A.S., Boucard A.A., Powell C.M., Südhof T.C. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. J Neurosci. 29(35): 10843-10854.

 

.2008

 

Proulx C.D., Holleran B.J., Boucard A.A., Escher E., Guillemette G., Leduc R. Mutational analysis of the conserved Asp2.50 and ERY motif reveals signaling bias of the urotensin II receptor. Mol Pharmacol. 74(3): 552-561.

 

Bolliger M.F., Pei J., Maxeiner S., Boucard A.A., Grishin N.V., Südhof T.C. Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A. 105(17): 6421-6426.

 

.2007

 

Araç D., Boucard, A.A., Strop, P., Sudhof, T.C. & Brunger, A.T. Structures of Neuroligin-1, and the Neuroligin-1/β-Neurexin-1 complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron 56(6): 992-1003.

 

.2006

Comoletti, D., Flynn, R. E., Boucard, A.A., Demeler, B., Shirf, V., Shi, J., Jennings, L.L., Newlin, H.R., Sudhof, T.C. & Taylor, P. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry 45(42): 12816-12827.

 

.2005

 

Boucard A.A., Chubykin, A. A., Comoletti, D., Taylor, P. & Sudhof T.C. A Splice-code for trans-synaptic cell adhesion mediated by binding of Neuroligin 1 to a- and b-Neurexins. Neuron 48 (2): 229-236.

 

.2004

 

Martin, S.S., Boucard, A.A., Clément, M., Escher, E., Leduc, R. & Guillemette G. Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine-scanning mutagenesis. J. Biol. Chem. 279 (49): 51415-51423.

 

.2003

 

Boucard, A.A., Roy, M., Beaulieu, M.E., Lavigne, P., Escher, E., Guillemette, G. & Leduc, R. Constitutive activation of the Angiotensin II type-1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket. J. Biol. Chem. 278 (38) : 36628-36636.

 

Boucard, A.A., Sauvé, S., Guillemette, G., Escher, E. & Leduc, R. Photolabelling the rat urotensinII/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain. Biochem. J. 370 (Pt. 3): 829-838.

 

.2002

 

Rihakova, L., Deraet, M., Auger-Messier, M., Pérodin, J., Boucard, A.A., Guillemette, G., Leduc, R., Lavigne, P. & Escher, E. Methionine proximity assay, a novel method for exploring peptide-ligand interaction. J. Recept. Signal Transduct. Res. 22 (1-4): 297-313.

 

Pérodin, J., Deraet, M, .Auger-Messier, M., Boucard, A.A., Rihakova, L., Beaulieu, M.E., Lavigne, P., Parent, J.L., Guillemette, G., Leduc, R. & Escher, E. Residues 293 and 294 are ligand contact points for the human angiotensin type 1 receptor. Biochemistry 41(48): 14348-14356.

 

Deraet, M., Rhihakova, L., Boucard, A.A., Sauvé, S., Mathieu, A.P., Guillemette,G., Leduc, R., Lavigne, P. & Escher, E. Angiotensin II bound to both receptors AT1 and AT2, parallel to the transmembrane domains and in an extended form. Can J Physiol Pharmacol. 80(5): 418-425.

 

.2001

 

Pérodin, J, Boucard, A.A., Leduc, R., Escher, E. & Guillemette, G. Assays for radiolabel-photoaffinity labeling of Angiotensin receptors. Methods Mol. Med. 51: 297-303.

 

.2000

 

Boucard A.A., Wilkes, B.C., Laporte, S.A., Escher, E., Guillemette, G. & Leduc, R. Photolabeling identifies position 172 of the human AT1 receptor as a ligand contact point: receptor-bound angiotensin II adopts an extended structure. Biochemistry 39(32): 9662-9670.

 

.1999

 

Laporte, S.A., Boucard, A.A., Servant, G., Guillemette, G., Leduc, R. & Guillemette, G. Determination of peptide contact points in the human angiotensin II type I receptor (AT1) with photosensitive analogs of angiotensin II. Mol Endocrinol. 13(4): 578-586.

 

 

.Book Chapters

 

Pérodin, J, Boucard, A.A., Leduc, R., Escher, E. & Guillemette, G. (2000). Assays for radiolabel-photoaffinity labeling of angiotensin receptors. Methods in Molecular Medecine vol. 51: Angiotensin Protocols, editors D.H. Wang, Humana Press Inc., Totowa, NJ.

 

Powell,C.M., Boucard, A. A. (2010) Neurexins and neuroligins: synaptic bridges implicated in autism. The Neurochemical Basis of Autism: From molecules to minicolumns, editors Gene J. Blatt, Springer, New York.

 

Powell,C.M., Boucard, A.A. (2012) Neuroligins and Neurexins: Bridging the synaptic cleft in Autism. The Autisms: Molecules to Model Systems, editors Powell C.M. & Monteggia L.M., Oxford University Press, New York.